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CCR2a Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Supplier: Proteintech Group Inc 161531AP150UL
Description
This antibody 16153-1-AP is raised against the peptide of 344-358 amino acids of CCR2a. It is specific to CCR2a.
CCR2, a chemokine receptor, is a regulator of monocyte/macrophage trafficking and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.Specifications
CCR2a | |
Polyclonal | |
Unconjugated | |
CCR2 | |
C C chemokine receptor type 2, C C CKR 2, CC CKR 2, CCR 2, CCR2, CCR2a, CCR2b, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP 1 R | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
729230 | |
-20°C | |
Liquid |
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot | |
0.37 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P41597 | |
CCR2 | |
Peptide | |
150 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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