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CCR4 Mouse anti-Human, Clone: 4A3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524390

Catalog No. PIMA524390


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Description

Description

Peptide Sequence: LPFELGKLFQ LQTLGLKGNP LTQDILNLYQ EPDGTRRLLN YLLDNLSGTA KRITTEQPPP RSWIMLQEPD RTRPTALFSV MCYNVLCDKY ATRQLYGYC

CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.
Specifications

Specifications

CCR4
Monoclonal
Unconjugated
CCR4
Liquid
CCR4
CNOT6 (NP_056270.2, 112 a.a. ∽ 210 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Protein A
RUO
Antibody
Monoclonal
Human
ELISA
4A3
PBS with no preservative; pH 7.4
P51679
CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5, C-C CKR-4, C-C chemokine receptor type 4, CCR-4, chemokine (C-C) receptor 4
Mouse
IgG2b, kappa
100 μg
-20° C
Primary
1233
Documents
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