Invitrogen™ CD105 Monoclonal Antibody (SN6), FITC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA180943

Catalog No. MA180943

Description

For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Mouse anti Human CD105 antibody, clone SN6 recognizes the human endoglin, also known as CD105. CD105 is a glycoprotein homodimer of approximately 95 kDa subunits expressed by endothelial cells, activated monocytes and some leukemia cells.

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

Specifications

• Antigen: CD105
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 1% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P17813
• Gene Symbols: ENG
• Immunogen: Cell membrane antigens from fresh leukemia cells.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Monkey, Horse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: SN6
• Conjugate: FITC
• Gene: ENG
• Gene Alias: AI528660; AI662476; CD105; CD105 antigen; cell surface MJ7/18 antigen; Edg; END; Endo; Endoglin; endoglin (Osler-Rendu-Weber syndrome 1); Eng; HHT1; ORW; ORW1; S-endoglin; transmembrane glycoprotein
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100070421, 2022
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
• Form: Liquid