CD112 (Nectin-2) Monoclonal Antibody (R2.477), PE, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
12-112-841	Invitrogen™ 12112841	25 Tests
12-112-842	Invitrogen™ 12112842	100 Tests

Description

This R2.477 MAb reacts with human CD112 (also known as Nectin-2 or Poliovirus Receptor Related 2), a 60-65 kDa immunoglobulin-like transmembrane cell adhesion molecule. This cell surface molecule is expressed on hematopoietic cells, endothelial, epithelial, as well as tumor cell lines such as Jurkat, U937, and MCF7. CD112 is a ligand for DNAM-1 (CD226), a leukocyte adhesion molecule expressed on natural killer (NK) cells. Interaction between CD112 and DNAM-1 promotes NK cytotoxic activity, leading to tumor cell lysis. In addition to its role in tumor suppression, CD112 plays a cooperative role in cell-cell adhesion, particularly in the formation of adherens junctions between neighboring epithelial cells and fibroblasts. CD112 can form homophilic and heterophilic interactions to regulate contact inhibition of cell movement and proliferation. Finally, CD112 has been reported to be a receptor for herpesvirus entry into cells. This MAb has been reported to block cell adhesion and herpesvirus entry.

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Specifications

• Antigen: CD112 (Nectin-2)
• Concentration: 5 μL/Test
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with BSA and 0.09% sodium azide; pH 7.2
• Gene Alias: AI325026; AI987993; CD112; herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; hveB; mHveB; MPH; Murine herpes virus entry protein B; murine herpesvirus entry protein B; nectin cell adhesion molecule 2; Nectin2; Nectin-2; Poliovirus receptor homolog; poliovirus receptor related 2; poliovirus receptor-like 2; poliovirus receptor-related 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); poliovirus receptor-related protein 2; poliovirus sensitivity; PRR2; Pvr; Pvrl2; PVRR2; Pvs
• Gene Symbols: NECTIN2
• Primary or Secondary: Primary
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Gene: NECTIN2

• Clone: R2.477
• Applications: Flow Cytometry
• Conjugate: PE
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: Q92692
• Gene ID (Entrez): 5819
• Isotype: IgG1 κ
• Purification Method: Affinity chromatography
• Product Type: Antibody