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Thermo Scientific™ Lab Vision™ CD115/c-fms/CSF-1R/M-CSFR Ab-1, Rat Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.

Manufacturer:  Thermo Scientific™ RT601P0

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Catalog No. RT601P0

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ CD115/c-fms/CSF-1R/M-CSFR Ab-1, Rat Monoclonal Antibody.

CD115, also known as c-fms, macrophage Colony Stimulating Factor Receptor (M-CSFR), or CSF-1R, exists in immature (gp130c-fms) and mature (gp150c-fms) forms. CSF-1R exhibits an intrinsic tyrosine-specific protein kinase activity. It is expressed on the cells of the mononuclear phagocyte lineage. CSF-1R is an integral transmembrane glycoprotein consisting of a 512 amino acid extracellular domain that includes the CSF-1 binding site, a single 25 amino acid membrane-spanning segment, and a 435 amino acid cytoplasmic portion that includes the tyrosine kinase domain.

Host Species: Rat

Clone: 2-4A5-4

Isotype: IgG1/κ

Species Reactivity: Human. Does not react with mouse and cat. Others not known.

Epitope: aa 349-512

Immunogen: v-ras-transformed rat NRK cells expressing transduced human CSF-1R

Molecular Weight: 130 and 150 kDa

Positive Control: Tonsil

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Acetone-fixed frozen)
  • Immunofluorescence
  • Blocks Ligand Binding
  • Blocks Ligand-dependent Proliferation
  • Inhibits CSF-1-independent Growth of Cells Expressing Mutant CSF-1R

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

CD115
Monoclonal
200µg/mL
Concentrated
v-ras-transformed rat NRK cells expressing transduced human CSF-1R
100μL
Primary
Monoclonal
Immunohistochemistry (Frozen)
2-4A5-4
Unconjugated
Rat
IgG2a kappa
RUO
Primary
Human
SDS
Documents
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