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c-Kit Rat anti-Mouse, Alexa Fluor® 647, Clone: 2B8, Invitrogen™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

Manufacturer:  Invitrogen RM6221

Catalog No. 50-113-7600


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Description

Description

c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1&2 signaling pathway.
Specifications

Specifications

c-Kit
Monoclonal
Alexa Fluor® 647
Kit
Liquid
Kit
IL-3-dependent mast cells derived from normal bone marrow.
Purified
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
2B8
PBS with 0.09% sodium azide; pH 7.2
P05532
C-Kit, CD117, PBT, SCFR, mast/stem cell growth factor receptor Kit, p145 c-kit, piebald trait protein, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, soluble KIT variant 1, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, ckit
Rat
IgG2b, kappa
1 mL
4° C
Primary
16590
Documents
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