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MilliporeSigma™ CD117 (c-Kit), Rat, PE-Cy7, Clone: ACK2,

Rat Monoclonal Antibody

$136.00 - $231.50

Specifications

Antigen CD117 (c-Kit)
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Clone ACK2
Host Species Rat
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Conjugate Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Conjugate Price Quantity & Availability  
MABF1498MI View Documents MilliporeSigma™
MABF1498
25μg PE-Cyanine7 Each for $136.00
Add to cart
 
MABF1499MI View Documents MilliporeSigma™
MABF1499
100μg PE-Cyanine7 Each for $231.50
Add to cart
 
Description

Description

The ACK2 antibody is specific for CD117, also called c-Kit, a 145kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo. Please choose the appropriate format for each application. In addition, the antibody is reported to be cross-reactive with rat c-Kit and is extensively published for use in this species.
Specifications

Specifications

CD117 (c-Kit)
Monoclonal
Rat
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Stable for 1 year at 2°-8°C from date of receipt. Note: It is recommended to store the product undiluted at 2°-8°C and protected from prolonged exposure to light. Do not freeze.
Primary
ACK2
Purified
Flow Cytometry
RUO

For Research Use Only. Not for use in diagnostic procedures.

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