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CD119 (IFN gamma Receptor 1) Armenian Hamster anti-Mouse, PE, Clone: 2E2, eBioscience™ Non-distribution product as customer accommodation.

Armenian Hamster Monoclonal Antibody

Manufacturer:  Invitrogen 12119182

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Catalog No. 50-112-2260


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Description

Description

Description: The monoclonal antibody 2E2 recognizes mouse CD119 also known as IFN gamma receptor1. CD119 heterodimerizes with IFN gamma receptor 2 (AF-1) forming the Class II cytokine receptor. The ligand IFN gamma binds IFN gamma receptor 1 subunit but signal transduction transpires via the IFN gamma receptor 2 subunit. The receptor is involved in host defense and expression is broad including B cells, NK cells, macrophages and dendritic cells as well as other non-hematopoietic cell types. Applications Reported: This 2E2 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 2E2 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. In addition, longer incubations appear to help stain the popµLation; therefore we recommend a 60 minute incubation at 2-8°C. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 µm post-manufacturing filtered.

This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
Specifications

Specifications

CD119 (IFN gamma Receptor 1)
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P15261
Ifngr1
IgG
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
15979
Flow Cytometry
2E2
PE
Ifngr1
Liquid
Armenian Hamster
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
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