Description: The monoclonal antibody reacts with human CD119 also known as the IFN gamma receptor 1 (alpha chain). IFN gamma R1 is found in a complex with IFN gamma receptor beta and recognizes with high affinity IFN gamma. Expression is ubiquitous but low, although some cell types, such as monocytes express higher levels. The GIR-208 monoclonal antibody is blocked from binding when IFN gamma is bound to the receptor. Applications Reported: This GIR-208 (GIR 208) antibody has been reported for use in flow cytometric analysis. Applications Tested: This GIR-208 (GIR 208) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 µm post-manufacturing filtered.This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
|CD119 (IFN gamma Receptor 1)|
|4° C, store in dark, DO NOT FREEZE!|
|GIR-208 (GIR 208)|
|PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2|
For Research Use Only.
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