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CD11b/c Mouse anti-Rat, PE, Clone: OX-42, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MR6204

Catalog No. 50-113-7540


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Description

Description

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. CD11b is also a receptor for fibrogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% thymocytes and is commonly used as a microgial marker in nervous tissue. CD11c encodes the integrin alpha X chain protein. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Mutations affecting the CD11b/c gene lead to systemic lupus erythematosus 6.
Specifications

Specifications

CD11b/c, CD11B/C
Monoclonal
0.1 mg/mL
PBS with 4mg/mL BSA, sucrose and 0.1% sodium azide
Liquid
Itgam, Itgax
Rat peritoneal cells
Purified
RUO
Antibody
Monoclonal
Rat
Flow Cytometry
OX-42
PE
Itgax
Itgax, Itgam, CD11B, CR3A, MAC-1, MAC1A, MGC117044, MO1A, SLEB6, CD11bc
Mouse
IgG2a, kappa
500 μL
4° C
Primary
25021, 499271
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