CD11c Mouse anti-Human, PE/Cy5.5, Clone: ITGAX/1243, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP254432PECY55
DescriptionCD11c Monoclonal antibody specifically detects CD11c in Human samples. It is validated for Flow Cytometry.
|Recombinant fragment (191 Amino acid residues between aa 600-850) of human ITGAX protein|
|Protein A or G purified|
|Dendritic Cell Markers, Signal Transduction|
|PBS with 0.05% Sodium Azide|
|95, 95 alpha chain, 95, alpha subunit, CD11 antigen-like family member C, CD11c, CD11c antigen, CD11Cleu M5, alpha subunit, integrin alpha-X, integrin, alpha X (antigen CD11C (p150), alpha polypeptide), integrin, alpha X (complement component 3 receptor 4 subunit), Leu M5, Leukocyte adhesion glycoprotein p150, Leukocyte adhesion receptor p150, leukocyte surface antigen p150, myeloid membrane antigen, alpha subunit, p150 95 integrin alpha chain, SLEB6|
|Store at 4°C in the dark. Do not freeze.|
|Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues|
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