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CD11c Mouse anti-Human, PE-Cyanine7, Clone: ITGAX/1242, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP254431PECY7

Catalog No. N254431PEC7


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Description

Description

CD11c Monoclonal antibody specifically detects CD11c in Human samples. It is validated for Flow Cytometry.
Specifications

Specifications

CD11c
ITGAX/1242
Flow Cytometry
Conjugated, Purified
ITGAX
Recombinant fragment (191 Amino acid residues between aa 600-850) of human ITGAX protein
Protein A or G purified
Dendritic Cell Markers, Signal Transduction
Primary
3687.0
Human
Flow Cytometry
PE-Cyanine7
PBS with 0.05% Sodium Azide
95, 95 alpha chain, 95, alpha subunit, CD11 antigen-like family member C, CD11c, CD11c antigen, CD11Cleu M5, alpha subunit, integrin alpha-X, integrin, alpha X (antigen CD11C (p150), alpha polypeptide), integrin, alpha X (complement component 3 receptor 4 subunit), Leu M5, Leukocyte adhesion glycoprotein p150, Leukocyte adhesion receptor p150, leukocyte surface antigen p150, myeloid membrane antigen, alpha subunit, p150 95 integrin alpha chain, SLEB6
Mouse
IgG2b Kappa
0.1 mL
Store at 4°C in the dark. Do not freeze.
Monoclonal
Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
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