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CD127/IL7R Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group Inc 176261AP150UL

Encompass_Preferred

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Catalog No. 50-173-1691


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Description

Description

CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. CD127 consists of an alpha chain and a gamma chain. The gamma (c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. The biological effects of IL7 are mediated by the binding of IL7 to the specific cell surface receptor. Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.
Specifications

Specifications

CD127/IL7R
Polyclonal
Unconjugated
IL7R
CD127, CDW127, IL 7 receptor subunit alpha, IL 7R alpha, IL 7R subunit alpha, IL 7RA, IL7R, IL7RA, ILRA, interleukin 7 receptor
Rabbit
Antigen Affinity Chromatography
RUO
16197, 3575
-20°C
Liquid
Flow Cytometry, Immunoprecipitation, Western Blot
0.15 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P16871, P16872
IL7R
CD127/IL7R Fusion Protein Ag11844
150 μL
Primary
Human, Mouse
Antibody
IgG
SDS
Documents
Product Certifications
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