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CD127/IL7R Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 176261AP

Catalog No. 50-173-1691


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Description

Description

CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. CD127 consists of an alpha chain and a gamma chain. The gamma (c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. The biological effects of IL7 are mediated by the binding of IL7 to the specific cell surface receptor. Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.
Specifications

Specifications

CD127/IL7R
0.15 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P16871, P16872
CD127, CDW127, IL 7 receptor subunit alpha, IL 7R alpha, IL 7R subunit alpha, IL 7RA, IL7R, IL7RA, ILRA, interleukin 7 receptor
Rabbit
IgG
150 μL
-20°C
Primary
16197, 3575
Flow Cytometry, Immunoprecipitation, Western Blot
Unconjugated
IL7R
Liquid
IL7R
CD127/IL7R Fusion Protein Ag11844
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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