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GP130 Mouse anti-Human, Biotin, Clone: AN-G30, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$108.00 - $235.00

Specifications

Antigen CD130 (GP130)
Clone AN-G30
Target Species Human
Conjugate Biotin
Isotype IgG2a
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-117-47 Non-distribution product as customer accommodation.
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Invitrogen
13130880
25 μg Each for $108.00
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50-117-48 Non-distribution product as customer accommodation.
View Documents
Invitrogen
13130882
100 μg Each for $235.00
Add to cart
 
Description

Description

Description: The AN-G30 monoclonal antibody reacts with human gp130, also known as CD130. gp130 is the common receptor subunit for the IL-6 family of cytokines, including IL-6, IL-11, IL-27, Oncostatin M, and LIF. gp130 is expressed on numerous cell types, including T cells, mast cells, and epithelial cells. Soluble forms of gp130 have been isolated from human serum samples. Upon ligand binding, gp130 signals via the JAK-STAT, MAPK, and PI3 kinase pathways Applications Reported: This AN-G30 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, and immunoblotting (WB). Applications Tested: This AN-G30 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 µm post-manufacturing filtered.

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Specifications

Specifications

CD130 (GP130)
Human
IgG2a
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
AN-G30
Biotin
Flow Cytometry, Immunoprecipitation, Western Blot
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.

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