CD137 (4-1BB) Ab-1 Mouse Monoclonal Antibody, Epredia™

Epredia™ CD137 (4-1BB) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.

Supplier:  Epredia MS621B

Catalog No. MS621B

Description

4-1BB (also known as CD137) is an inducible receptor-like protein expressed on the cell surface of activated splenic T cells and thymocytes. It exists as both a monomer and a dimer on the surface of activated T cells. 4-1BB is structurally related to the members of NGFR/TNFR superfamily which are characterized by the presence of three-six patterns of a cysteine-rich motif in their extracellular domains. Other members of this family include low affinity NGFR, two receptors for TNF (TNFR-I & TNFR-II), CD30, CD40, OX40, Fas, and CD27. These molecules are involved in cell growth, survival, and death processes. The cytoplasmic domain of 4-1BB include two runs of acidic amino acids, a potential p56^lck binding site, five consecutive glycines at the C-terminus, and four potential phosphorylation sites: one tyrosine, two threonine, and one serine.

Host Species: Mouse

Clone: BBK-2

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: Ectodomain

Immunogen: Ectodomain of human 4-1BB recombinant protein

Molecular Weight: 30kDa

Positive Control: Spleen, thymus or tonsil

Cellular Localization: Membrane

Recommended for:

• Immunofluorescence
• Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: CD137 Ab-1
• Classification: Monoclonal
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 1 mL
• Research Discipline: Apoptosis
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry, Immunofluorescence
• Clone: BBK-2
• Conjugate: Biotin
• Immunogen: Ectodomain of human 4-1BB recombinant protein
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated