Thermo Scientific Lab Vision CD137 (4-1BB) Ab-1, Mouse Monoclonal Antibody
Ensure accurate, reproducible results in immunofluorescence and flow cytometry applications with Thermo Scientific CD137 (4-1BB) Ab-1, Mouse Monoclonal Antibody.
Manufacturer: Thermo Scientific MS621PABX
Ensure accurate, reproducible results in immunofluorescence and flow cytometry applications with Thermo Scientific CD137 (4-1BB) Ab-1, Mouse Monoclonal Antibody.4-1BB (also known as CD137) is an inducible receptor-like protein expressed on the cell surface of activated splenic T cells and thymocytes. It exists as both a monomer and a dimer on the surface of activated T cells. 4-1BB is structurally related to the members of NGFR/TNFR superfamily which are characterized by the presence of three-six patterns of a cysteine-rich motif in their extracellular domains. Other members of this family include low affinity NGFR, two receptors for TNF (TNFR-I & TNFR-II), CD30, CD40, OX40, Fas, and CD27. These molecules are involved in cell growth, survival, and death processes. The cytoplasmic domain of 4-1BB include two runs of acidic amino acids, a potential p56lck binding site, five consecutive glycines at the C-terminus, and four potential phosphorylation sites: one tyrosine, two threonine, and one serine.
Host Species: Mouse
Species Reactivity: Human. Others not known.
Immunogen: Ectodomain of human 4-1BB recombinant protein
Molecular Weight: 30kDa
Positive Control: Spleen, thymus or tonsil
Cellular Localization: Membrane
- Flow Cytometry
USA: RUO; Int'l: RUO
|Ectodomain of human 4-1BB recombinant protein|
|Flow Cytometry, Immunofluorescence|
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