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CD14 Mouse anti-Human, APC-Cyanine7, Clone: 61D3, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen A15453

Catalog No. 50-113-7718


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Description

Description

CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.
Specifications

Specifications

CD14
Monoclonal
0.1 mg/mL
PBS with proprietary stabilizer and 0.1% sodium azide
P08571
monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein
Mouse
IgG1
100 μg
Immunology
Antibody
Monoclonal
Human
Flow Cytometry
61D3
APC-Cyanine7
CD14
Liquid
CD14
Human CD14
Purified
RUO
4° C
Primary
929
Documents
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