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CD14 Mouse anti-Human, PE-Texas Red®, Clone: TuK4, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MHCD1417

Catalog No. 50-112-1348


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Description

Description

The R-phycoerythrin (PE)-Texas Red™ conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.

CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.
Specifications

Specifications

CD14
Monoclonal
PE-Texas Red™
CD14
Liquid
CD14
Human CD14
Purified
ASR
Antibody
Monoclonal
Human
Flow Cytometry
TuK4
PBS with BSA, sucrose and 0.1% sodium azide
P08571
monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein
Mouse
IgG2a
0.5 mL
4° C, store in dark
Primary
929
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