Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

CD141 Rat anti-Mouse, PE, Clone: LS17-9, eBioscience™ Invitrogen™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

Catalog No. 12-141-182


Add to cart

Description

Description

The MAb LS17-9 recognizes mouse CD141 (Thrombomodulin, BDCA-3), a type I cell surface glycoprotein that binds to and allosterically activates thrombin. This complex cleaves protein C and the Thrombin Activatable Fibrinolysis Inhibitor (TAFI), initiating an important anticoagulant and antifibrinolytic pathway. Although expressed across many tissues and cell types, its highest expression has been reported on the lumenal surface of vascular endothelial cell. In the immune system the highest expression can be observed on monocytes and macrophages. Soluble CD141 is constitutively present in the serum at a very low level, and can be upregulated during inflammation. The anti-inflammatory activity of CD141 results from its ability to block the highly pro-inflammatory activity of thrombin. CD141 prevents chemotaxis and binding of granulocytes to activated endothelium, and inhibits activation of eosinophils and mast cells thereby reducing inflammation. Although human CD141 is commonly used as a marker of cross-presenting dendritic cells, mouse CD141 does not exhibit the same expression pattern.

CD141 Monoclonal antibody specifically detects CD141 in Mouse samples. It is validated for Flow Cytometry
Specifications

Specifications

Liquid
Flow Cytometry
LS17-9
PE
THBD
AHUS6; AI385582; BDCA3; BDCA-3; CD141; CD141 antigen; DC141; fetomodulin; sCD141; snoRNA MBII-339; soluble CD141; THBD; THPH12; THRM; thrombomdulin; thrombomodulin; TM
IgG2a, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
21824
CD141
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P15306
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
SDS
Documents
Product Certifications
Provide Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit