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CD146/MCAM Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 175641AP

Catalog No. 50-173-1648


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Description

Description

CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 is expressed at cell-cell junctions in all endothelial cells, and has also been observed in other normal and maligt cell types. In addition to its recognized role as a calcium-independent cell adhesion molecule, CD146 may also act as a signal transduction molecule in the recruitment of Fyn kinase, and in the subsequent tyrosine-phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. CD146 expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Further, CD146 could be an adhesion molecule active in neural crest cells during embryonic development. CD146 acts also as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Specifications

Specifications

CD146/MCAM
0.4 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P43121, Q8R2Y2, Q9EPF2
CD146, MCAM, MUC18
Rabbit
IgG
150 μL
-20°C
Primary
4162, 78967, 84004
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Unconjugated
MCAM
Liquid
MCAM
CD146/MCAM Fusion Protein Ag11762
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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