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CD161 Mouse anti-Human, FITC, Clone: B199.2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA528121

Catalog No. PIMA528121


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Description

Description

This antibody recognizes a similar epitope to the DX1 monoclonal antibody.

KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Specifications

Specifications

CD161
Monoclonal
1 mg/mL
PBS with 1% BSA and 0.09% sodium azide
Q12918
KLRB1
Purified human NK cells cultured in IL-2
Protein G
RUO
Antibody
Monoclonal
Human
Flow Cytometry
B199.2
FITC
KLRB1
Liquid
Mouse
IgG1
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Primary
3820
Documents
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