CD171 Mouse anti-Human, APC, Clone: eBio5G3 (5G3), eBioscience
Mouse Monoclonal Antibody
Manufacturer: Invitrogen 17171941
The monoclonal antibody eBio5G3 recognizes CD171 also known as neural cell adhesion molecule L1. CD171 is a member of the Ig superfamily containing 6 extracellular Ig domains and five fibronectin type III-like repeats. CD171 has been shown to function as a cell adhesion molecule mediating homotypic and heterotypic cell-cell interactions in neuronal myelination, neurite outgrowth and regeneration. Expression of CD171 has been found on monocytes and mature monocytic-derived and follicular DCs, a minor subset of lymphocytes in addition to that found on neuronal tissue and some tumor cells lines. Expression of CD171 on tumors is thought to contribute to tumor progression. Epitope of eBio5G3 is in amino-terminal Ig-like domain. This eBio5G3 (5G3) antibody has been pre-titrated and tested by flow cytometric analysis of the tumor cell line Panc-1. This can be used at 5 µL (0.06 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 105 to 108 cells/test. Filtration: 0.2 µm post-manufacturing filtered.L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
|PBS with 0.1% Gelatin, 0.2% BSA and 0.09% Sodium Azide; pH 7.2|
|CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAML1, S10, SPG1|
|4° C, store in dark, DO NOT FREEZE!|
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