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CD18 (LFA-1 beta) Mouse anti-Human, Clone: MEM-148, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA528115

Catalog No. PIMA528115


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Description

Description

CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes. CD18 can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, and these heterodimers are known to participate in the process of cell adhesion as well as cell-surface mediated signaling. CD18 forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits, and these integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. Defects in the CD18 gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the CD18 protein have been identified.
Specifications

Specifications

CD18 (LFA-1 beta)
Monoclonal
1 mg/mL
PBS with no preservative
P05107
ITGB2
Peripheral blood mononuclear cells
Protein G
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Immunoprecipitation, Western Blot
MEM-148
Unconjugated
ITGB2
Liquid
Mouse
IgG1
1 mg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3689
Documents
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