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CD185 (CXCR5) Monoclonal Antibody (MU5UBEE), PE-Cyanine7, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Supplier: Invitrogen 25918541
Description
Description: The MU5UBEE monoclonal antibody reacts with human and non-human primate CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt's lymphoma. In peripheral blood, CD185 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), as well as on a subpopulation of memory (CD45RO+) T cells. Circulating CD185+ T cells are in a resting state and migrate to the lymph nodes due to expression of CCR7 and CD62L. In tonsil, CD185 is expressed on nearly all CD4+ cells together with CD45RO and activation markers such as CD69 and ICOS. Tonsillar CD185+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing help to B cells. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell follicles of germinal centers in response to CXCL13, making CD185 an established marker of follicular helper T cells. The MU5UBEE monoclonal antibody also crossreacts with Rhesus macaque. Applications Reported: This MU5UBEE antibody has been reported for use in flow cytometric analysis. Applications Tested: This MU5UBEE antibody has been pre-titrated and tested by flwo cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.06 μg) per test.
CD185 (CXCR5) Monoclonal antibody specifically detects CD185 (CXCR5) in Human, Non-human Primate, Rhesus Monkey samples. It is validated for Flow Cytometry.Specifications
CD185 (CXCR5) | |
Monoclonal | |
5 μL/Test | |
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2 | |
P32302 | |
CXCR5 | |
N-terminal extracellular domain | |
25 Tests | |
Primary | |
Human, Non-human Primate, Rhesus Monkey | |
Antibody | |
IgG2b κ |
Flow Cytometry | |
MU5UBEE | |
PE-Cyanine7 | |
CXCR5 | |
Blr1; Blr-1; Burkitt lymphoma receptor 1; burkitt lymphoma receptor 1 homolog; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; CD185; CD185 antigen; chemochine (C-X-C motif) receptor 5; chemokine (C-X-C motif) receptor 5; CXC; C-X-C chemokine receptor type 5; CXC motif chemokine; C-X-C motif chemokine receptor 5; CXCR5; CXC-R5; CXCR-5; EGK_06966; Fusin; Gpcr6; GPR9; HUMSTR; LESTR; MDR15; MDR-15; Monocyte-derived receptor 15; neurolymphatic receptor; NLR | |
Mouse | |
Affinity chromatography | |
RUO | |
643, 701792 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
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For Research Use Only.