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CD185 (CXCR5) Mouse anti-Non-human Primate, Rhesus Monkey, PE, Clone: 87.1, eBioscience™ Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

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Catalog No. 12-185-942


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Description

Description

This 87.1 MAb reacts with Non-human Primate (specifically rhesus) CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt's lymphoma. In peripheral blood, CD185 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), and a subpopulation of memory (CD45RO+) T cells. CD185+ circulating T cells are in a resting state and migrate to the lymph nodes due to CCR7 and CD62L expression. In tonsils, CD185 is expressed on nearly all CD4+ cells along with CD45RO and the activation markers CD69 and ICOS. Tonsillar CD185+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing B cell help. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular CXCL13-induced T cell migration into the B cell follicles of germinal centers. Thus, CD185 is an established marker of follicular helper T cells (Tfh). In rhesus macaques, infection with simian immunodeficiency virus (SIV) has been reported to increase the number of germinal centers and Tfh cells within the lymph nodes. Refer to the rhesus reactive alternative clone MU5UBEE (cat. 12-9185) for identification of CXCR5 on T cells in addition to B cells.

CD185 (CXCR5) Monoclonal antibody specifically detects CD185 (CXCR5) in Non-human Primate, Rhesus Monkey samples. It is validated for Flow Cytometry
Specifications

Specifications

Liquid
Flow Cytometry
87.1
PE
CXCR5
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Non-human Primate, Rhesus Monkey
CD185 (CXCR5)
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Blr1; Blr-1; Burkitt lymphoma receptor 1; burkitt lymphoma receptor 1 homolog; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; CD185; CD185 antigen; chemochine (C-X-C motif) receptor 5; chemokine (C-X-C motif) receptor 5; CXC; C-X-C chemokine receptor type 5; CXC motif chemokine; C-X-C motif chemokine receptor 5; CXCR5; CXC-R5; CXCR-5; EGK_06966; Fusin; Gpcr6; GPR9; HUMSTR; LESTR; MDR15; MDR-15; monocyte-derived receptor 15; Neurolymphatic receptor; NLR
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
701792
SDS
Documents
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