CD19 Mouse anti-Human, Monkey, Clone: CVID3/155, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP2619080.1MG
DescriptionCD19 Monoclonal antibody specifically detects CD19 in Human,Monkey samples. It is validated for Flow Cytometry,Immunocytochemistry,Immunofluorescence.
|10 mM PBS with no preservative|
|Recombinant human CD19 protein|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence|
|Flow Cytometry 0.5 - 1 μg/million cells in 0.1 ml, Immunocytochemistry/Immunofluorescence 0.5 - 1.0 μ/mL, SDS-Page|
|B4, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, CD19 antigen, CD19 molecule, CVID3, Differentiation antigen CD19, MGC12802, T-cell surface antigen Leu-12|
|Store at 4°C.|
|Recognizes a protein of 95kDa, identified as CD19. CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is present in both benign and malignant B-cells and is considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue, CD19 is observed in germinal centers, in mantle zone cells, and in scattered cells of the inter-follicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However, in contrast to CD20, expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative, as are T-cell neoplasms.|
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