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CD19 Monoclonal Antibody (6OMP31), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Supplier: Invitrogen 53019480
Description
Description: The 6OMP31 monoclonal antibody reacts with human, mouse, and rat CD19. CD19 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD19 was first identified as the B4 antigen of human B lymphocytes using the anti-B4 monoclonal. It is expressed by B cells during all stages of development, except on terminally differentiated plasma cells, and on follicular dendritic cells. CD19 acts primarily as a B cell co-receptor and together with CD21, CD81, Leu13, and MHC class II forms a multi-molecular complex that associates with the BCR. CD19 plays a role in the development, activation, differentiation, and proliferation of B cells. CD19 deficiency leads to an overall impaired humoral immune response. Mutations in CD19 have been associated with severe immunodeficiency syndromes. Although it is unclear whether CD19 contributes directly to B cell carcinogenesis, it is expressed on most B cell tumors, such as acute lymphoblastic leukemias and B cell lymphomas. The use of CD19 monoclonal antibodies for therapies against lymphoma, leukemia and autoimmune disorders are currently being explored. Applications Reported: This 6OMP31 antibody has been reported for use in immunohistochemical staining of frozen tissue sections, and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.
CD19 Monoclonal antibody specifically detects CD19 in Human, Mouse, Rat samples. It is validated for Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin).Specifications
CD19 | |
Monoclonal | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
P15391, P25918 | |
Cd19 | |
Affinity chromatography | |
RUO | |
12478, 365367, 930 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin) | |
6OMP31 | |
Alexa Fluor 488 | |
Cd19 | |
AW495831; B4; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Cd19; CD19 antigen; CD19 molecule; CVID3; differentiation antigen CD19; Leu-12; T-cell surface antigen Leu-12 | |
Rat | |
25 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG2a κ |
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For Research Use Only.