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CD197 (CCR7) Monoclonal Antibody (4B12), PE-Cyanine7, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Supplier: Invitrogen 25197181
Description
Description: The 4B12 monoclonal antibody reacts with mouse CCR7, also known as EBI-1 and CD197. CCR7 is a chemokine receptor for the chemokines CCL19 (CK?11, ELC, MIP3?, Scya19, Exodus-3) and CCL21 (CK?9, SLC, MIP2?, Scya21, Exodus-2). In recent years, the role of chemokines in directing the migration of lymphocytes has been well-characterized. One of the most important mediators of homeostatic trafficking of naive T cells to secondary lymphoid organs (SLO) is the chemokine receptor CCR7. Binding of its ligands, CCL19 and CCL21, mediates the trans endothelial migration of T cells across high endothelial venules into SLO. It has also been demonstrated that CCR7 plays a role in the localization of dendritic cells and B cells during an immune response. CCR7 is a chemokine receptor for the chemokines CCL19 (CK?11, ELC, MIP3?, Scya19, Exodus-3) and CCL21 (CK?9, SLC, MIP2?, Scya21, Exodus-2). In addition to its significant role in the chemotaxis of lymphocytes, human CCR7 has also been recognized as a marker for a distinct subset of memory T cells, the central memory (TCM) population. These cells are characterized by the expression of CCR7 and CD62L and reside within peripheral lymphoid organs. CCR7 also plays a role in thymocyte development and its deficiency leads to disturbed thymic architecture, aberrant T cell development, and limited thymocyte expansion.
CD197 (CCR7) Monoclonal antibody specifically detects CD197 (CCR7) in Mouse samples. It is validated for Flow Cytometry.Specifications
CD197 (CCR7) | |
Monoclonal | |
0.2 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
P47774 | |
Ccr7 | |
Affinity chromatography | |
RUO | |
12775 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
4B12 | |
PE-Cyanine7 | |
Ccr7 | |
BLR2; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; C-C chemokine receptor type 7; C-C CKR-7; C-C motif chemokine receptor 7; CC-CKR-7; CCR7; CCR-7; CD197; CDw197; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; Cmkbr7; EBI1; Ebi1h; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor | |
Rat | |
50 μg | |
Primary | |
Mouse | |
Antibody | |
IgG2a κ |
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For Research Use Only.