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CD2 Mouse anti-Human, Qdot® 605, Clone: S5.5, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen Q10172

Catalog No. 50-113-7563


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Description

Description

CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction betwee CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.
Specifications

Specifications

CD2, CD2
Monoclonal
Qdot® 605
CD2
Liquid
CD2
CD2 antigen.
Purified
RUO
Antibody
Monoclonal
Human
Flow Cytometry
S5.5
0.05M borate with 1M betaine and 0.05% sodium azide; pH 8.3
P06729
CD2 antigen, sheep red blood cell receptor, LFA-3 receptor, T-cell surface antigen CD2, T-cell surface antigen T11/Leu-5, erythrocyte receptor, lymphocyte-function antigen-2, rosette receptor
Mouse
IgG2a
100 μL
4° C
Primary
914
Documents
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