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CD201 (EPCR) Rat anti-Human, APC, Clone: RCR-227, eBioscience™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

$289.00

Specifications

Antigen CD201 (EPCR)
Clone RCR-227
Target Species Human
Conjugate APC
Isotype IgG1, kappa
View More Specs

Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-112-3100 Non-distribution product as customer accommodation. View Documents Invitrogen
17201842
100 Tests Each for $289.00
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Description

Description

Description: The monoclonal antibody RCR-227 reacts with human CD201, which is also known as the endothelial protein C receptor (EPCR), a 46-kDa transmembrane protein related to class I MHC. CD201 was originally identified on vascular endothelium cells, predomitly larger blood vessels. It is also expressed on monocytes, lymphocytes, hematopoietic stem cells, neutrophils, and eosinophils. CD201 serves as a binding site for protein C, activated protein C (APC), and factor VII/VIIa. A soluble form has also been identified in the plasma. CD201 plays a role in controlling coagulation as disruption of its gene in mice caused placental thrombosis and early embryonic death. This cell surface molecule is also involved in the anti-inflammatory response. APC binding to CD201 enables PAR-1 activation that confers cytoprotective effects. In monocytes, APC binding decreases secretion of proinflammatory cytokines, chemokines, and growth factors. Finally, CD201 has been shown to inhibit lymphocyte migration. Applications Reported: This RCR-227 antibody has been reported for use in flow cytometric analysis. Applications Tested: This RCR-227 antibody has been pre-titrated and tested by flow cytometric analysis of HUVECs. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL.

Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 µm post-manufacturing filtered. The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregcy.
Specifications

Specifications

CD201 (EPCR)
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
RCR-227
APC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.

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