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CD202b (TIE2) Monoclonal Antibody (33.1), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
$420.00
Specifications
Antigen | CD202b (TIE2) |
---|---|
Clone | 33.1 |
Concentration | 0.5 mg/mL |
Applications | Western Blot |
Classification | Monoclonal |
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
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Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-245-552
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Invitrogen
14202982 |
100 μg |
Each of 1 for $420.00
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Description
Description: This 33.1 monoclonal antibody reacts with human, mouse, rabbit, rat, pig, and zebrafish CD202b. Also known as Tie-2, this molecule is a member of the tyrosine kinase receptor family. CD202b is expressed on endothelial and a subset of hematopoietic cells and is believed to play a role in both angiogenesis and hematopoiesis during development of the mouse embryo. In fetal liver and adult bone marrow, Tie-2 is expressed by a subpopulation of hematopoietic progenitor cells characterized as Lineage markers-, c-Kit+, Sca1+ cells. Long-term multilineage repopulating cells were detected in Tie-2+, Lineage-, c-Kit+, Sca1+ cells but not in Tie-2-, Lineage-, c-Kit+, Sca1+ cells. Applications Reported: This 33.1 antibody has been reported for use in western blotting. Applications Tested: This 33.1 antibody has been tested by immunoblotting of reduced cell lysate prepared from the bEND3 cell line at less than or equal to 5 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.Specifications
CD202b (TIE2) | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
Q02763, Q02858 | |
TEK | |
Primary | |
4° C | |
TEK |
33.1 | |
Western Blot | |
Unconjugated | |
Mouse | |
Human, Mouse, Porcine, Rabbit, Rat | |
100356675, 21687, 396729, 7010, 89804 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.
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