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Invitrogen™ CD204 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA116825
Description
Suggested positive control: antigen standard for MSR1 (transient overexpression lysate), mouse liver lysate, mouse liver protein.
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
Specifications
CD204 | |
Polyclonal | |
Unconjugated | |
MSR1 | |
bovine scavenger receptor type II; CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor 1; macrophage scavenger receptor type III; macrophage scavenger receptor types I and II; MRS-A; MSR; Msr1; MSR-A; phSR1; phSR2; RGD1564316; SCARA1; Scavenger receptor class A member 1; scavenger receptor class A, member 1; scavenger receptor type A; scavenger receptor type I; Scvr; SRA; SR-A; SR-AI; SR-AI/II; SR-AII | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
4481 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot, Immunocytochemistry | |
0.97 mg/mL | |
TBS with 0.05% sodium azide | |
P21757 | |
MSR1 | |
A synthetic peptide made to an internal portion of human Macrophage Scavenger Receptor I (between residues 300-350). [UniProt P21757]. | |
100 μL | |
Primary | |
Human, Monkey | |
Antibody | |
IgG |
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