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CD217 (IL-17Ra) Monoclonal Antibody (PAJ-17R), PE, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Supplier: Invitrogen 12718280
Description
Description: The monoclonal antibody PAJ-17R recognizes mouse IL-17 receptor A (IL-17RA) also known as CD217. This single transmembrane domain-containing receptor can homo- or heterodimerize with IL-17RC or IL-17RB. IL-17RA binds to IL-17A, IL-17F(cytokines of the Th 17 lineage), or IL-17E (IL-25). Ligand binding to the single subunit of IL-17RA has been shown to induce homo- or heterodimerization of the receptor complex that in turn recruits Act-1 via the SEFIR domains leading to recruitment of TRAF6 and signaling through the NFkappaB and MAPK pathways. Initial reports suggested ubiquitous expression of IL-17RA based on binding studies with IL-17-Fc and expression of mRNA. Interestingly, despite this, not all cells expressing the receptor respond to IL-17A. In particular, resting T cells do not respond. It is not known if the expression level of IL-17RA protein varies or if some cells express the receptor but are not able to activate downstream signaling events. Recent evidence suggests a more limited expression profile based on IL-17RA knock-out mice which display decreased numbers of neutrophils with impaired function in response to challenge with K. pneumonia or Candida albicans. This suggests IL-17RA plays a more domit and critical role in neutrophil development and function. Our studies suggest that expression can be found on abundantly on Gr-1^dim population and many of the Gr-1^bright bone marrow cells, as well as some F4/80 positive cells.
Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F. IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections.Specifications
CD217 (IL-17Ra) | |
Monoclonal | |
0.2 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
Q60943 | |
Il17ra | |
Affinity chromatography | |
RUO | |
16172 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
PAJ-17R | |
PE | |
Il17ra | |
AW538159; CANDF5; CD127; CD217; CDw217; hIL-17R; IL-17 receptor A; IL17R; Il17ra; IL-17RA; interleukin 17 receptor A; interleukin-17 receptor A; MGC10262; VDw217 | |
Rat | |
25 μg | |
Primary | |
Mouse | |
Antibody | |
IgG2a |
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For Research Use Only.