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CD22 Mouse anti-Human, FITC, Clone: RFB-4, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MHCD2201

Catalog No. 50-112-1382


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Description

Description

Commonly used, FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.

CD22 (BL-CAM) is a type 1 integral membrane glycoprotein with molecular weight of 130 to 140 kDa. CD22 is expressed in both the cytoplasm and cell membrane of B-lymphocytes. CD22 antigen appears early in B-cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Unlike other B-cell markers, CD22 membrane expression is limited to the late differentiation stages comprised between mature B cells (CD22+) and plasma cells (CD22-), and may thus prove useful in phenotyping mature leukemias. CD22 is also strongly expressed in hairy cell leukemia. CD22 preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. CD22 is also strongly expressed in hairy cell leukemia. CD22 is also positive in diffuse large B-cell lymphoma and nodular lymphocyte predomice Hodgkin’s lymphoma, but negative in classical Hodgkin’s lymphoma.
Specifications

Specifications

CD22
Monoclonal
FITC
CD22
Liquid
CD22
Human CD22
Purified
ASR
Antibody
Monoclonal
Human
Flow Cytometry
RFB-4
PBS with 4mg/mL BSA and 0.1% sodium azide
P20273
FLJ22814, MGC130020, SIGLEC-2, SIGLEC2, B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, CD22 antigen, T-cell surface antigen Leu-14, sialic acid binding Ig-like lectin 2, sialic acid-binding Ig-like lectin 2
Mouse
IgG1
0.5 mL
4° C, store in dark
Primary
933
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