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CD289 (TLR9) Rat anti-Human, Clone: eB72-1665, eBioscience™ Invitrogen™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

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Catalog No. 14-909-937


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Description

Description

eB72-1665 is generated against a portion of human toll-like receptor 9 (aa 273-288), a molecule reported to be expressed predominantly intracellularly. TLR9 is a ∽115-120 kDa molecule, which mediates response to unmethylated CpG dinucleotides in bacterial DNA. CpG DNA induces a strong T-helper-1-like inflammatory response and the proliferation of TLR9-positive human B cells. When stimulated with CpG DNA, TLR9-deficient (TLR9-/-) mice lacked splenocyte proliferation, inflammatory cytokine production from macrophages, and dendritic cell maturation, as compared with normal mice. To date, at least twelve members of the Toll family have been identified. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Members of the TLR family are involved in recognition and response to different microbial components including lipoproteins, peptidoglycans, and nucleic acids and play important roles in innate immunity and inflammation.

CD289 (TLR9) Monoclonal antibody specifically detects CD289 (TLR9) in Human samples. It is validated for Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Specifications

Specifications

CD289 (TLR9)
Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
eB72-1665
Unconjugated
Tlr9
CD289; Tlr9; toll like receptor 9; toll-like receptor 9; UNQ5798/PRO19605
IgG2a, kappa
2 mg
4° C
Primary
54106
Liquid
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9NR96
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Human
SDS
Documents
Product Certifications
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