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CD3 Mouse anti-Canine, Human, Clone: OTI3E10, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA506064

Catalog No. 50-167-6421


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Description

Description

CD3 epsilon is part of the CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in this gene are associated with T cell immunodeficiency and has been linked to Type 1 Diabetes deficiency in women.
Specifications

Specifications

CD3
Monoclonal
Unconjugated
CD3E
Liquid
CD3E
Full length human recombit protein of human CD3E produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Canine, Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI3E10
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P07766, P27597
IMD18; T3E; TCRE; HCD3
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
442981, 916
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