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CD3 Mouse anti-Human, PerCP, Clone: S4.1 (7D6), Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MHCD0331

Catalog No. 50-112-1305


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Description

Description

PerCP conjugates are excited by the 488 nm line of the argon-ion laser and have a large Stokes shift, providing minimal spectral overlap into the R-PE (phycoerythrin) channel.

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Specifications

Specifications

CD3
Monoclonal
PerCP
CD3E
Liquid
CD247, CD3D, CD3E, CD3G
Human CD3
Affinity chromatography
ASR
Antibody
Monoclonal
Human
Flow Cytometry
S4.1 (7D6)
PBS with BSA, sucrose and 0.1% sodium azide
P04234, P07766, P09693, P20963
CD3-DELTA; T3D; CD3 antigen; delta subunit; CD3 delta; CD3d antigen; delta polypeptide TiT3 complex; OKT3; delta chain; T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 delta chain; CD3/TCR complex; HCD3
Mouse
IgG2a
0.5 mL
4° C, store in dark
Primary
915, 916, 917, 919
Documents
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