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CD303a Mouse anti-Human, eFluor® 450, Clone: 201A, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen 48981842

Catalog No. 50-112-8779


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Description

Description

Description: This 201A monoclonal antibody reacts with human CD303a, which is also known as CLEC4C or Blood Dendritic Cell Antigen 2 (BDCA-2). This type II transmembrane protein is expressed almost exclusively on plasmacytoid dendritic cells, which secrete type I interferon during antiviral and antitumor responses. Studies have demonstrated that CD303a binds asialo-galactosyl-oligosaccharides on invading pathogens, resulting in the activation of signaling pathways that lead to CD303a internalization and downregulation of interferon production. Applications Reported: This 201A antibody has been reported for use in flow cytometric analysis. Applications Tested: This 201A antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. eFluor® 450 is an alternative to Pacific Blue®. eFluor® 450 emits at 445 nm and is excited with the Violet laser (405 nm). Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser. Filtration: 0.2 µm post-manufacturing filtered.

This gene encodes a member of the C-type lectin/C-type lectin-like domain superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene.
Specifications

Specifications

CD303a
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Q8WTT0
C-type lectin superfamily member 7, Blood dendritic cell antigen 2 protein, BDCA-2, Dendritic lectin, CD303 antigen, CLEC4C, BDCA2, CLECSF11, CLECSF7, DLEC, HECL, C-type lectin domain family 4 member C
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
201A
eFluor™ 450
CLEC4C
Liquid
CLEC4C
IgG2a, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
170482
Documents
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