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CD314 (NKG2D) Rat anti-Mouse, Functional Grade, Clone: MI-6 (MI6), eBioscience™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

$195.00 - $524.00

Specifications

Antigen CD314 (NKG2D)
Clone MI-6 (MI6)
Target Species Mouse
Conjugate Functional Grade
Isotype IgG2a, lambda
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Products 4
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-145-91 Non-distribution product as customer accommodation.
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Invitrogen
16588082
100 μg
Each for $195.00
Add to cart
 
50-145-92 Non-distribution product as customer accommodation.
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Invitrogen
16588085
500 μg
Each for $311.00
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50-145-93 Non-distribution product as customer accommodation.
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Invitrogen
16588086
1 mg
Each for $524.00
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50-145-90 Non-distribution product as customer accommodation.
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Invitrogen
16588081
50 μg This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

Description: The MI-6 monoclonal antibody reacts with the mouse NKG2D, a lectin-like molecule expressed on both human and mouse NK cells. Mouse NKG2D binds to retinoic acid-inducible RAE-1 alpha, beta, gamma, delta, epsilon and the minor histocompatibility molecule H60 and has the ability to costimulate multiple NK activation receptors, through the DAP12/DAP10 adaptor molecules. NKG2D is expressed by all spleen and liver NK cells, NK1.1(+) thymocytes, in vitro activated LAK cells, and a subset of splenic NKT cells. Applications Reported: This MI-6 (MI6) antibody has been reported for use in flow cytometric analysis. Furthermore, engagement of NKG2D with the MI-6 monoclonal antibody has been demonstrated to block NKG2D-mediated cytolysis, both in vitro and in vivo . Applications Tested: This MI-6 (MI6) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment. Filtration: 0.2 µm post-manufacturing filtered.

Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.
Specifications

Specifications

CD314 (NKG2D)
Mouse
IgG2a, lambda
Monoclonal
Liquid
Antibody
4° C
MI-6 (MI6)
Functional Grade
Flow Cytometry, Functional Assay, Neutralization
Primary
Monoclonal
PBS with no preservative; pH 7.2
RUO
SDS

For Research Use Only.

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