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CD339 (Jagged 1) Armenian Hamster anti-Mouse, Rat, PE, Clone: HMJ1-29, eBioscience™

Armenian Hamster Monoclonal Antibody

$170.00 - $341.00

Specifications

Antigen CD339 (Jagged 1)
Clone HMJ1-29
Target Species Mouse, Rat
Conjugate PE
Isotype IgG
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-107-62
Encompass
View Documents
Invitrogen
12339180
25 μg
Each for $170.00
Add to cart
 
50-107-63
Encompass
View Documents
Invitrogen
12339182
100 μg
Each for $341.00
Add to cart
 
Description

Description

Description: This HMJ1-29 monoclonal antibody reacts with mouse Jagged-1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g. Notch 1-4), Jagged-1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Jagged-1 is expressed by thymic lymphoid and stromal cells, as well as macrophages and CD8+CD11c+ dendritic cells in the spleen. The HMJ1-29 antibody is reported to crossreact to rat. Applications Reported: This HMJ1-29 antibody has been reported for use in flow cytometric analysis. Applications Tested: This HMJ1-29 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered.

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
Specifications

Specifications

CD339 (Jagged 1)
Mouse, Rat
IgG
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO
HMJ1-29
PE
Flow Cytometry
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
SDS
Product Certifications

For Research Use Only.

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