CD35 Mouse anti-Human, Monkey, Alexa Fluor 350, Clone: E11, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP233080AF350
DescriptionCD35 Monoclonal antibody specifically detects CD35 in Human, Monkey samples. It is validated for ELISA.
|complement component (3b/4b) receptor 1 (Knops blood group), KN|
|Store at 4°C in the dark.|
|Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This MAb is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. This MAb is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This MAb labels follicular dendritic cells and follicular dendritic cell sarcoma.|
|Alexa Fluor™ 350|
|50 mM sodium borate with 0.05% sodium azide|
|Intact human monocytes were used as immunogen to generate the CD35 antibody (Hogg et al, 1984).|
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