CD36 Monoclonal Antibody (TR9), APC, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA110210

Catalog No. PIMA110210

Description

CD36 (fatty acid translocase, FAT) is an 88 kDa, ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not by follicular and B1 B cells, and is rapidly induced on Follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similar to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids. CD36 is preferentially found within lipid rafts, which facilitates its association with receptors, signaling and adapter molecules. CD36 binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. Further, CD36 may function as a cell adhesion molecule and directly mediates cyto-adherence of Plasmodium falciparum parasitized erythrocytes. Mutations in the CD36 gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the CD36 protein have been found.

Specifications

• Antigen: CD36
• Classification: Monoclonal
• Conjugate: APC
• Gene Accession No.: P16671
• Gene Symbols: CD36
• Immunogen: Platelets
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: TR9
• Gene: CD36
• Gene Alias: FAT, GPIV, Scarb3, GPIIIB, PAS IV, PAS-4, fatty acid translocase, glycoprotein IIIb, platelet glycoprotein 4, platelet glycoprotein IV
• Host Species: Mouse
• Purification Method: Size-exclusion chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 948
• Content And Storage: 4° C, store in dark, DO NOT FREEZE!
• Form: Liquid