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CD365 (TIM-1) Rat anti-Mouse, PE, Clone: RMT1-4, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 566335

Catalog No. BDB566335



The RMT1-4 monoclonal antibody specifically recognizes CD365 which is encoded by Havcr1 /(Hepatitis A virus cellular receptor 1) and commonly known as T cell immunoglobulin and mucin domain-containing protein 1 (TIM-1). TIM-1 is a type I transmembrane glycoprotein that contains an extracellular immunoglobulin V-like domain and mucin-like domain and a conserved intracellular tyrosine phosphorylation motif that is involved in transmembrane signaling. TIM-1 is a costimulatory molecule that plays an important role in regulating immune responses. It is expressed on mast cells, and activated T cells including T helper type 2 (Th2) cells. TIM-1 is constitutively expressed by some B cells with increased TIM-1 expression detected upon B cell activation. TIM-1 was reportedly expressed by the majority of IL-10-expressing regulatory B cells within several major splenic B cell subsets. These cells may play critical roles in Th2-like CD4 T cell differentiation and in the regulation of inflammation and autoimmunity. TIM-4, a phosphatidylserine receptor encoded by Timd4 /, is a putative ligand for TIM-1.

R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.


CD365 (TIM-1)
Aqueous buffered solution containing ≤0.09% sodium azide.
Havcr1, Tim1, TIMD-1, Timd1, KIM-1, Kidney injury molecule 1
Mouse TIM-1 Recombinant Protein
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Affinity Purified
Rat SD, also known as Sprague-Dawley (outbred) IgG2b, κ
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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