CD365 (TIM-1) Rat anti-Mouse, PE, Clone: RMT1-4, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 566335
The RMT1-4 monoclonal antibody specifically recognizes CD365 which is encoded by Havcr1 /(Hepatitis A virus cellular receptor 1) and commonly known as T cell immunoglobulin and mucin domain-containing protein 1 (TIM-1). TIM-1 is a type I transmembrane glycoprotein that contains an extracellular immunoglobulin V-like domain and mucin-like domain and a conserved intracellular tyrosine phosphorylation motif that is involved in transmembrane signaling. TIM-1 is a costimulatory molecule that plays an important role in regulating immune responses. It is expressed on mast cells, and activated T cells including T helper type 2 (Th2) cells. TIM-1 is constitutively expressed by some B cells with increased TIM-1 expression detected upon B cell activation. TIM-1 was reportedly expressed by the majority of IL-10-expressing regulatory B cells within several major splenic B cell subsets. These cells may play critical roles in Th2-like CD4 T cell differentiation and in the regulation of inflammation and autoimmunity. TIM-4, a phosphatidylserine receptor encoded by Timd4 /, is a putative ligand for TIM-1.R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Havcr1, Tim1, TIMD-1, Timd1, KIM-1, Kidney injury molecule 1|
|Mouse TIM-1 Recombinant Protein|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.|
|Rat SD, also known as Sprague-Dawley (outbred) IgG2b, κ|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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