CD38 Monoclonal Antibody (ICO-20), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA17653

Catalog No. 01-670-387

Description

MA1-7653 detects CD38 from human samples. MA1-7653 has been successfully used in ELISA and Immunoprecipitation procedures. The MA1-7653 immunogen is Hematopoietic precursors, thymocytes, activated T-cells and plasma cells. Store at 4oC short term. Store at -80oC long term.

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

Specifications

• Antigen: CD38
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.2
• Gene Accession No.: P28907
• Gene Symbols: CD38
• Immunogen: Hematopoietic precursors, thymocytes, activated T-cells and plasma cells.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Immunoprecipitation
• Clone: ICO-20
• Conjugate: Unconjugated
• Gene: CD38
• Gene Alias: 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADPRC 1; ADPRC1; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; Cd38; CD38 antigen; CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase); CD38 antigen (p45); CD38 antigen p45; CD38 molecule; CD38H; Cd38-rs1; cluster of differentiation 38; cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; I-19; NAD(+) nucleosidase; NAD+ nucleosidase; NIM-R5 antigen; T10
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 952
• Content And Storage: 4°C short term, -80°C long term
• Form: Liquid