CD4 Monoclonal Antibody (KEN-4), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA181754

Catalog No. PIMA181754

Description

For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL. Mouse anti Rabbit CD4 antibody, clone KEN-4 recognizes the rabbit CD4 cell surface antigen, a 50 kDa glycoprotein expressed by T helper cells.Mouse anti Rabbit CD4 antibody, clone KEN-4 blocks the allogeneic mixed lymphocyte reaction response.

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

Specifications

• Antigen: CD4
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Gene: CD4
• Gene Alias: CD4 antigen p55, CD4 receptor, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100009152
• Content And Storage: 4°C or -20°C if preferred
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation
• Clone: KEN-4
• Conjugate: Unconjugated
• Gene Accession No.: P46630
• Gene Symbols: CD4
• Immunogen: Rabbit thymocytes.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Rabbit
• Product Type: Antibody
• Isotype: IgG2a