CD4 Mouse anti-Human, Alexa Fluor 750, Clone: 11830, R&D Systems
Mouse Monoclonal Antibody
Manufacturer: R&D Systems FAB3791S100
DescriptionCD4 is a 54-60kDa type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed predominantly on hematopoietic cells such as T cells, monocytes and Langerhans cells. T cells known to be positive for CD4 include Th1, Th2, Th17, Th22, Th9, Tfh and Treg subsets, plus select thymocytes. CD4 exists as either an oxidized monomer (3 internal disulfide bonds), a reduced monomer (2 internal disulfide bonds) and a disulfide-linked dimer. CD4 functions in collaboration with the T cell receptor in the recognition of peptide antigens that are presented by class II major histocompatibility complexes. In particular, CD4 in its dimeric form binds to the MHC complex at non-polymorphic sites. Monomeric CD4 has also been shown to be a coreceptor for HIV entry and specifically to bind gp120, the external envelope glycoprotein of HIV. Over amino acids (aa) 26-396 (the extracellular domain), human and mouse CD4 share 58% aa sequence identity.
|Flow Cytometry 5 uL/10^6 cells|
|CD4, CD4 antigen, CD4 antigen (p55), CD4 molecule, CD4 receptor, CD4mut, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4|
|Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.|
|Detects human CD4 in direct ELISAs and Western blots. Does not cross-react with recombinant mouse CD4.|
|Alexa Fluor 750|
|Supplied in a saline solution containing BSA and Sodium Azide. with Sodium Azide|
|Recombinant human CD4, Extracellular domain, Accession # P01730|
|Protein A or G purified from hybridoma culture supernatant|
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