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CD43 Mouse anti-Human, APC, Clone: L10, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MHCD4305

Catalog No. 50-112-1413


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Description

Description

Allophycocyanin (APC) is a stable and highly soluble phycobiliprotein that provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing exceptional quantum yields and molar extinction coefficients.

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability. CD43 appears to be an important modulator of leukocyte functions. Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.
Specifications

Specifications

CD43
Monoclonal
APC
SPN
Liquid
SPN
Human CD43
Purified
ASR
Antibody
Monoclonal
Human
Flow Cytometry
L10
PBS with 10% sucrose, BSA and 0.1% sodium azide
P16150
CD43, GALGP, GPL115, LSN, galactoglycoprotein, leukocyte sialoglycoprotein, leukosialin, sialophorin gpL115, leukosialin, CD43
Mouse
IgG1
0.5 mL
4° C, store in dark
Primary
6693
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