CD44var (v3) Mouse anti-Human, Clone: VFF-327v3, eBioscience
Mouse Monoclonal Antibody
Manufacturer: Invitrogen BMS144
Description: Specifically recognizes an epitope encoded by exon v3 on the variant portion of human CD44. Standard CD44 (CD44s) lacks the entire variable region and is found mainly in cells of lymphohematopoietic origin. The multiple isoforms (designated CD44v; v = variant) contain alternatively spliced exons inserted within the extracellular domain. These isoforms are known as CD44v1, CD44v2, CD44v3, CD44v4, CD44v5, CD44v6, CD44v7, CD44v8, CD44v9, CD44v10, CD44v11. Applications Tested: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blotting.CD44 cell surface antigen is a 100kDa glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predomit CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential.
|PBS with no preservative; pH 7.2-7.4|
|CDW44, CSPG8, ECMR-III, HCELL, IN, LHR, MC56, MDU2, MDU3, MGC10468, MIC4, MUTCH-I, Pgp1|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
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