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CD44var (v4) Rat anti-Mouse, Clone: 10D1, eBioscience™ Non-distribution product as customer accommodation.

Rat Monoclonal Antibody

Manufacturer:  Invitrogen BMS149

Catalog No. 50-178-10


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Description

Description

Description: Specifically recognizes an epitope encoded by exon v4 on the variant portion of mouse CD44. Standard CD44 (CD44s) lacks the entire variable region and is found mainly in cells of lymphohematopoietic origin. The multiple isoforms (designated CD44v; v = variant) contain alternatively spliced exons inserted within the extracellular domain. These isoforms are known as CD44v1, CD44v2, CD44v3, CD44v4, CD44v5, CD44v6, CD44v7, CD44v8, CD44v9, CD44v10, CD44v11. Applications Tested: ELISA, Immunohistochemistry, Western Blotting. Purity: >98%.

CD44 cell surface antigen is a 100kDa glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predomit CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential.
Specifications

Specifications

CD44var (v4)
Monoclonal
0.5 mg/mL
PBS with no preservative
P15379
RP23-203N8.3, AU023126, AW121933, AW146109, HERMES, Ly-24, Pgp-1
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
ELISA, Immunohistochemistry, Western Blot
10D1
Unconjugated
Cd44
Liquid
Cd44
IgG1, kappa
100 μg
4° C
Primary
12505
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